Osteobolin-C™

PROMOTES HEALTHY CARTILAGE, TENDON AND JOINT TISSUE Osteobolin-C approaches joint support from a completely unique angle. The primary ingredient in Osteobolin-C is Cissus Quadrangularis, a powerful Ayurvedic herb that has been proven in published laboratory research to promote bone and connective tissue repair.   The active phytosterols in Osteobolin-C also promotes healthy muscle tissue due to the pronounced anti-catabolic effects of blocking cortisol. Osteobolin-C users experience dramatic reduction in joint pain and increased mobility, along with accelerated recovery time after rigorous training or injury.   Aids in the recuperation and regeneration of cartilage, tendons, and joints Suppresses cortisol and promotes nutrient delivery into connective tissue A potent anti-catabolic that speeds recovery and supports lean muscle

FAQ

Q: When is the best time to take Osteobolin-C? A: Take first dose with breakfast, and second dose with dinner.  It can be taken with or without food Back to top Q:  How long will it take to feel the positive benefits of Osteobolin-C?  A: If taken at the recommended dosage, you should feel some reduction of joint and tendon pain within a few days.  In order to experience the full healing and repair effects of the compound, 2-3 weeks of usage is often necessary.  Long term users report minimal if any reoccurring pain in the effected areas.   Back to top Q:  What makes Osteobolin-C different than other bone and joint health products?  A: Glucosamine and chondroitin have been scientifically proven to aide in muscle and tissue repair, but take months for any effect to be noticed. Furthermore, only about half of the users experience any improvement at all, and it is very expensive. Osteobolin-C employs a completely different approach. Cissus quadrangularis is the active ingredient in Osteobolin-C, unique compound with many beneficial properties. It  has been shown to effectively block the destructive hormone cortisol, plus promote new tissue cell growth at the point of injury or inflammation. It also displays potent anti-inflammatory properties as well. Back to top Q: Has there been any scientific research on the healing potential of Osteobolin-C?     A: Our research shows that the use of Osteobolin-C on bone fractures can increase the healing process 30% faster that any other product available on the market. Cissus Quadrangularis is an ingredient used in ancient Chinese medicines and one of our main ingredients. It has been proven to have great healing qualities in the mineralization of bone. There is also ample empirical and anecdotal evidence of its positive healing effects on cartilage, tendon, and skeletal muscle.  Back to to Q:  Is it safe to use Osteobolin-C for long periods of time, or should I cycle it?  A: Osteobolin-C is very safe and can be taken continuously for both new and old injuries. It also serves as a great preventative supplement, as it helps keep connective tissue healthy and less prone to injury.  Back to top Q: How does Osteobolin-C limit the inflammatory process?    A:  Osteobolin-C minimizes myeloperoxidase activity. This is a process where enzymes are released to at the site of an injury which produce hypochlorous acid, which is toxic to cells. Myeloperoxidase can be considered a double-edged sword, in that while it kills bacteria and pathogens associated with the inflammatory process, it also kills healthy cells which are necessary for healing. By inhibiting this process, Osteobolin-C can attenuate pain and swelling associated with bone, tendon, and ligament damage, which allows for faster healing and a quicker time to recovery.     Back to top Q: Because of the above, will Osteobolin-C reduce my ability to fight infection?  A: Absolutely not. Cissus quadrangularis also has antibacterial and antimicrobial properties that far outweigh any loss of resistance to infection due to myeloperoxidase inhibition.  Back to top Q:Why is vitamin C necessary in the formula?    A: Vitamin C is an important part of the Osteobolin-C formula, because it converts proline to hydroxyproline, the main substance needed for the formation of collagen which is what aids in the natural development of tissue remodeling.    Back to top Q: Who can benefit from taking Osteobolin-C? A: This product is useful for any male or female over the age of 18 and who is had or currently has bone, tendon, or joint issues. It also can safely be used by anyone who is simply looking to maintain good connective tissue health. Virtually everyone can benefit from this product.  Back to top Q: What supplements do you recommend while taking Osteobolin-C to maximize results? A: We recommend whey protein supplementation, with a goal of attaining 1-1.5 grams of protein per day per pound of bodyweight. Additionally, we strongly encourage the use of an essential fatty acid product with omega 3/6/9 and a good multivitamin with minerals.  Back to top

Osteobolin-C

Cissus quadrangularis is a unique, versatile herb that has been used in Ayurvedic medicine for thousands of years.  Native to the warmer climates of Ceylon and India, it is documented in Ayurvedic texts as a powerful analgesic (1) that has the ability to inhibit stress-induced glucocorticoid activity (4), as well as the ability to accelerate healing in bone fractures (2).   Cissus Quadrangularis has also been shown to combat bacterial infections, while at the same time reducing the severity of ulcers (1).  Several unpublished case studies and large amounts of empirical data also suggest that taking cissus can mitigate tendon, ligament, joint and cartilage damage, acting as an analgesic while at the same time inhibiting inflammation-related damage (Applied Nutriceuticals Empirical Research).

 

Vitamin C (ascorbic acid) is an important compound in immune function and tissue repair.  It is required for the synthesis of important neurotransmitters, amino acids, and the synthesis of connective tissues (8).      Vitamin C also has strong antioxidant properties, enhances iron absorption, and is needed for the formation of cholesterol-based hormones (8).

 

Mechanism of Mechanical Remodeling 

In order to understand the true utility of Osteobolin-C as a joint, cartilage, and bone-enhancing compound, the connective tissue remodeling process (and how Osteobolin-C applies to it) must be discussed.  Connective tissue is found throughout the body, and consists of 4 classes: connective tissue proper (fibrous tissue of ligaments), cartilage, bone tissue, and blood.  All connective tissues have three main common elements: ground substance, fibers (collagen, elastic, and reticular), and cells (fibroblasts, chondroblasts, osteoblasts) (11).  Subsequently, fibroblasts are associated with connective tissue proper, chondroblasts with cartilage, and osteoblasts with bone.  The aforementioned “blast” cells synthesize the connective tissue matrix in mature mode, and the mature cells maintain the health of the matrix (11). 

 

In the event of a joint, cartilage, or tendon injury where the connective tissue matrix becomes damaged, several compounds found in Osteobolin-C allow for the rapid mobilization of fibroblasts, chondroblasts, and osteoblasts to the injured area, along with increased retention of calcium, phosphorous, collagen, and mucopolysaccharides (2).  With nutrients now flowing to the injured area, the increased calcium retention facilitates greater calcium uptake into connective tissue, giving it the remodeling materials (building blocks if you will) needed to assemble and heal an injury in a more timely fashion (3).  Osteobolin-C also attenuates neutrophil infiltration and pro-inflammatory cytokines (IL-1 and IL-8) which are commonplace in joint, bone, and tendon injuries (11).    Cytokines are protein-signaling compounds used for intercell communication (in this case signaling the cell to begin the inflammatory process) and neutrophils are the most abundant type of white blood cell (in this case for the removal of bacteria and other material from an injured area).  Both agents promote inflammation to the injured area, causing small blood vessels in the injured area to dilate.  This process is called hyperemia, and it contributes to the physiologic responses seen in this type of injury: pain, heat, and swelling in the afflicted area.  Also during this process, the enzyme myeloperoxidase is  released in the injured area whichin turn  produces hypochlorous acid (HOCl).  HOCl is cytotoxic (toxic to cells), so myeloperoxidase can be considered a double-edged sword, in that while it kills bacteria and pathogens associated with the inflammatory process, it also kills healthy cells which are necessary for healing.  

 

Osteobolin-C limits the inflammatory process and by minimizing myeloperoxidase activity in the damaged bone or connective tissue. Osteobolin-C through the process described above can attenuate pain and swelling associated with bone, tendon, and ligament damage, which allows for faster healing and a quicker time to recovery. Osteobolin-C can speed recovery from injuries that occur during training and every day life, plus it can it help reduce pain/discomfort from old injuries. Both anecdotal and scientific evidence exists proving that Osteobolin-C can alleviate pain, and in many cases has shown the ability to promote healing even in old injuries.

 

The Vitamin C contained in Osteobolin-C is important because it converts proline to hydroxyproline, the main substance needed for the formation of collagen, which is a very important structural element in tissue remodeling (8,11).  Scientific research has indicated that the use of Osteobolin-C can greatly speed up healing in the bone fracture process, as some studies have suggested up to a 30% increase in bone mineralization over a period of six weeks, resulting in drastically (up to 50%) reduced healing times in test subjects (2, 5). In some studies, cissus quadrangularis (the main ingredient in Osteobolin-C) has been shown to reduce healing time of bone fractures up to 53% (5). 

 

            Due to it’s universally beneficial effects, Osteobolin-C has the ability to address the needs of the all individuals, from those with low-to-average activity levels to the competitive athlete. Although a great deal of research exists on the fracture healing qualities of Osteobolin-C, the effect of Osteobolin-C on the joints and connective tissue has been under-researched.    However, a large amount of anecdotal data on athletes (track, weight lifting, and football) has been collected, with a growing assortment of anecdotal and empirical evidence that demonstrates the ability of Osteobolin-C  to speed recovery, ease pain, reduce inflammation, and subsequently reduce damage from hard training (9,10).  There is strong scientific evidence that Osteobolin-C’s ability to mobilize fibroblasts and chondroblasts to an injured area indicates that Osteobolin-C can also accelerate the process of regeneration in these tissues and aid in healing old injuries since these same compounds are precursors to cartilage, tendons, and ligaments, (9,10).  One case study involving a 42 year-old bodybuilder with a torn distal bicep tendon reported a reduction in healing time of about 40 % (9,10).

 

There are still many other extraordinary benefits to taking this amazing product. Osteobolin-C contains several important keto-steroids that, when ingested, exert various pro-anabolic actions.  Tetracyclic triterpenoids (steroidal saponins) are probably the most important of these keto-steroids, as they exert a marked anti-catabolic effect, and are responsible for the vast majority of Osteobolin-C-related anti-glucocorticoid actions (1,2,3,4,5).   The triterpenoids compete with cortisol for receptor sites, and have been shown to minimize the anti-anabolic actions of cortisol (5).   Vitamin C is also important in this process, because it also competes for glucocorticoid sites, thus further reducing the amount of cortisol that can bind to any given receptor (6,7,8).   Because Osteobolin-C is so versatile, dosages vary greatly, depending on the desired effect from the compound, and the anabolic dosage is higher than the therapeutic dosage.

 

            In conclusion, Osteobolin-C can be considered a highly effective means of preventative and retroactive treatment of training stress and injuries, through both analgesic and connective-tissue strengthening processes. 

 

1. Singh SP, Mishra N (1984) An experimental study of analgesic activity of Cissus quadrangularis. Ind. J Pharmac. 162.
2. Udupa KN, Guru P (1964) Further studies on the effect of Cissus quadrangularis in accelerating fracture healing.  Ind. Jour. Med. Res. 52(1).
3. Udupa KN, Guru P (1964) Biomechanical and calcium studies on the effect of Cissus quadrangularis in fracture repair. .  Ind. Jour. Med. Res. 52(5).
4. Udupa KN, Guru P (1963) Effect of Cissus quadrangularis The healing of cortisone treated fracture. Ind. Jour. Med. Res. 51(4).
5. Udupa KN (1962) Cissus quadrangularis in healing of fractures A clinical study J. Indian Medical Association. 38(11).
6. Chopra SS, Patel MR, Gupta LP, Datta IC (1975) Studies on Cissus q in Experimental Fracture Repair: Effect on Chemical parameters in the blood.  Ind. Jour. Med. Res. 63(6).
7. The Healing Factor: Vitamin C Against Disease (1996)  Irwin Stone.
8. Vit. C Requirments: Optimal Health Benefits v. Overdose (http://acu-cell.com/vitc.html) A moderately high does advocacy supporting site.
9. Unpublished Research- Applied Nutriceuticals Case Study: Healing of severely torn distal bicep tendon on 42 year-old weight lifter (2006).
10. Marieb, E. Human Anatomy and Physiology, 6th Edition.  (2004). Pearson Benjamin Cummings, San Francisco.

11. Devi, C, Shyamala, JM (2005) Attenuation of neutrophil infilatration and proinflammatory cytokines by Cissus Quadrangularis (CQE): a possible prevention against gastric ulcerogenesis. J Herb Pharmacother.  5(3): 33-42.

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